| 16214 Venkatachalam | February 4, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15111 Winters | February 6, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15118 Elizabethsears | February 28, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16219 Venturelli | February 29, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16221 Kevinyang | February 29, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16222 Donnanderson | February 29, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| (60524) 2000 EA40 | March 8, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15129 Sparks | March 9, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15133 Sullivan | March 9, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15139 Connormcarty | March 9, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15144 Araas | March 9, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16230 Benson | March 9, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15132 Steigmeyer | March 10, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15145 Ritageorge | March 10, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| (138252) 2000 FM58 | March 27, 2000 | Lowell Observatory Near-Earth-Object Search | asteroid |
| 15155 Ahn | March 29, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15160 Wygoda | March 29, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| HD 46375 b | March 29, 2000 | Geoffrey Marcy | exoplanet |
| (60737) 2000 GB87 | April 4, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| (60739) 2000 GR87 | April 4, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| (60723) 2000 GU73 | April 5, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| (60726) 2000 GE75 | April 5, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| (60728) 2000 GS76 | April 5, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| (60730) 2000 GC79 | April 5, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| (60731) 2000 GQ79 | April 5, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15559 Abigailhines | April 5, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15563 Remsberg | April 5, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15565 Benjaminsteele | April 5, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15567 Giacomelli | April 5, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15574 Stephaniehass | April 5, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15583 Hanick | April 5, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16236 Stebrehmer | April 5, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| (60732) 2000 GK80 | April 6, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| (60733) 2000 GL80 | April 6, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| (60734) 2000 GT80 | April 6, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| (60735) 2000 GF82 | April 7, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15599 Richardlarson | April 7, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15604 Fruits | April 7, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16238 Chappe | April 7, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 67308 Öveges | April 21, 2000 | Krisztián Sárneczky | asteroid |
| 16247 Esner | April 28, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15627 Hong | April 29, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15628 Gonzales | April 29, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16251 Barbifrank | April 29, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16252 Franfrost | April 29, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16254 Harper | April 29, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16258 Willhayes | May 6, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16271 Duanenichols | May 6, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16274 Pavlica | May 6, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 15635 Andrewhager | May 7, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16265 Lemay | May 7, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16266 Johconnell | May 7, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16267 Mcdermott | May 7, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16268 Mcneeley | May 7, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 16269 Merkord | May 7, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 109 Piscium b | June 2000 | Steven S. Vogt | exoplanet |
| 22134 Kirian | October 25, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 22151 Davebracy | November 21, 2000 | Lincoln Near-Earth Asteroid Research | asteroid |
| 607372 Colombounilanka | November 30, 2000 | Nalin Samarasinha | asteroid |
| 234292 Wolfganghansch | December 16, 2000 | Thierry Pauwels | asteroid |